San Francisco 49ers at Los Angeles Chargers — Week 15 Odds, Injuries & Prediction

San Francisco 49ers @ Los Angeles Chargers: live odds, injury report, team rankings comparison, and win probability for this matchup.

Thu, Dec 17 · 8:15 PM ET · Prime Video

Odds (DraftKings): LAC -2.5 · ML SF +120 / LAC -142 · O/U 47.5

Model prediction

Predicted winner: Los Angeles Chargers - SF 16% / LAC 84%

Team stats comparison (rank out of 32)

	SF offense	LAC offense	Edge
Total yards	#7	#12	away edge (5)
Rush yards	#24	#12	home edge (12)
Pass yards	#5	#18	away edge (13)

	SF defense	LAC defense	Edge
Total yards allowed	#20	#5	home edge (15)
Rush yards allowed	#11	#8	home edge (3)
Pass yards allowed	#25	#5	home edge (20)

Injury report

• Mike Evans (SF · WR) - questionable - Quad strain
• Rashawn Slater (LAC · LT) - questionable - Knee flare-up (surgically repaired patellar tendon)
• George Kittle (SF · TE) - out - Torn Achilles tendon
• Ricky Pearsall (SF · WR) - out - PCL knee surgery - season-ending
• Nick Bosa (SF · Edge) - out - Knee tendinitis (surgically repaired right knee)
• Tyler Biadasz (LAC · C) - out - ACL damage + additional left knee injuries

San Francisco 49ers full schedule · Los Angeles Chargers full schedule · See this week's full NFL odds and predictions on Blitz Odds